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Anil B Mukherjee Selected Research

Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)

1/2021Ablation of microRNA-155 and neuroinflammation in a mouse model of CLN1-disease.
1/2020Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis.
1/2019Cln3-mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl-protein thioesterases-1 (Ppt1)-protein and Ppt1-enzyme activity in the lysosome.
12/2015Suppression of agrin-22 production and synaptic dysfunction in Cln1 (-/-) mice.
8/2015Evaluation of disease progression in INCL by MR spectroscopy.
12/2014Mice homozygous for c.451C>T mutation in Cln1 gene recapitulate INCL phenotype.
8/2014Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study.
11/2013Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL.
5/2012The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol.
1/2012In a model of Batten disease, palmitoyl protein thioesterase-1 deficiency is associated with brown adipose tissue and thermoregulation abnormalities.
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Anil B Mukherjee Research Topics

Disease

17Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
01/2021 - 05/2006
6Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2020 - 11/2013
5Neoplasms (Cancer)
04/2010 - 07/2002
5Inflammation (Inflammations)
12/2007 - 05/2004
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2017 - 01/2012
3Asthma (Bronchial Asthma)
09/2011 - 03/2005
2Neuroinflammatory Diseases
01/2021 - 08/2015
2Hypothermia
01/2012 - 08/2009
1Inborn Genetic Diseases (Disease, Hereditary)
12/2014
1Persistent Vegetative State (Vegetative State)
08/2014
1Deficiency Diseases (Deficiency Disease)
11/2013
1Mitochondrial Diseases (Mitochondrial Disease)
01/2012
1Respiratory Sounds (Crackle)
09/2011
1Dyspnea (Shortness of Breath)
09/2011
1Melanoma (Melanoma, Malignant)
04/2010
1Bradycardia
08/2009
1Renal Insufficiency (Renal Failure)
03/2008
1IGA Glomerulonephritis (IGA Nephropathy)
03/2008
1Autoimmune Diseases (Autoimmune Disease)
12/2007
1Pulmonary Fibrosis (Fibrosing Alveolitis)
08/2006
1Premature Obstetric Labor (Premature Labor)
09/2005
1Infections
09/2005
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2005
1Carcinogenesis
07/2004
1Virus Diseases (Viral Diseases)
04/2004
1Pathologic Processes
07/2002

Drug/Important Bio-Agent (IBA)

15Proteins (Proteins, Gene)FDA Link
01/2019 - 07/2004
4UteroglobinIBA
03/2008 - 03/2005
3Lysergic Acid Diethylamide (LSD)IBA
01/2021 - 11/2013
3Pharmaceutical PreparationsIBA
11/2013 - 07/2002
3CytokinesIBA
09/2011 - 04/2004
3AllergensIBA
09/2011 - 03/2005
2CeroidIBA
12/2015 - 08/2015
1N-(tert-butyl)hydroxylamineIBA
01/2021
1Adenosine Triphosphatases (ATPase)IBA
01/2017
1Choline (Choline Chloride)IBA
08/2015
1Inositol (Myoinositol)IBA
08/2015
1HydrolasesIBA
08/2015
1Nonsense Codon (Nonsense Mutation)IBA
12/2014
1Acetylcysteine (Siran)FDA LinkGeneric
08/2014
1Cysteamine (Mercaptamine)FDA Link
08/2014
1AntioxidantsIBA
11/2013
1ResveratrolIBA
05/2012
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2012
1Immunoglobulin E (IgE)IBA
09/2011
1Matrix Metalloproteinases (MMPs)IBA
04/2010
1Immunoglobulin A (IgA)IBA
03/2008
1Heparin (Liquaemin)FDA LinkGeneric
03/2008
1Fibronectins (Fibronectin)IBA
03/2008
1Bleomycin (Blenoxane)FDA LinkGeneric
08/2006
1Carrier Proteins (Binding Protein)IBA
03/2006
1ProstaglandinsIBA
11/2005
1LipidsIBA
09/2005
1DinoprostIBA
09/2005
1Interleukin-13IBA
03/2005
1InterleukinsIBA
03/2005
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
03/2005
1CarcinogensIBA
07/2004
14- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA
07/2004
1SmokeIBA
07/2004
1Fas Ligand Protein (Fas Ligand)IBA
07/2004
1Prostaglandin D2IBA
05/2004
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
07/2002
1StaurosporineIBA
07/2002

Therapy/Procedure

2Investigational Therapies (Experimental Therapy)
08/2014 - 01/2012
2Anesthesia
01/2012 - 08/2009
1Rewarming
08/2009
1General Anesthesia
08/2009